rkakkar@chemistry.du.ac.in The oxidative stress can be effectively neutralized by enhancing cellular defenses in the form of … Gallic acid is used a remote astringent in cases of internal haemorrhage. Interestingly, a phenolic compound like GA was recently associated with cell death caused by The diverse range of applications of this simple polyphenol is due to a fine amalgam between its antioxidant and prooxidant potential. Esters of gallic acid have a diverse range of industrial uses, as antioxidants in food, in cosmetics, and in the pharmaceutical industry. A push‐pull effect is always necessary, and ester or amide bonds seem well adapted to increase the antioxidant efficiency. It has been shown to exhibit numerous biological and pharmacological properties, including antiviral, antibacterial, and antitumor activities in numerous human cancer cell lines. Starting from the bioavailability and the biosynthetic pathway of gallic acid, this review includes various in vitro, in vivo and in silico studies providing the mode of action, radical scavenging activity, ability to inhibit lipid peroxidation, maintenance of endogenous defense systems and metal ion chelation by this triphenolic molecule, along with a comprehensive overview of factors responsible for its high antioxidant activity. It is a white solid, although samples are typically brown owing to partial oxidation. is available on our Permission Requests page. Fetching data from CrossRef. Gallic acid is a trihydroxybenzoic acid found in many plants as either the free acid or in the esterified form of gallotannins and ellagitannins. J-STAGE, Japan Science and Technology Information Aggregator, Electronic. USA.gov. This invention relates to additives for methanesulfonic acid based tin and tin alloy plating formulations. Gallic acid was found to show cytotoxicity against cancer cells, without harming healthy cells. Zein/Phospholipid Composite Nanoparticles for Successful Delivery of Gallic Acid into aHSCs: Influence of Size, Surface Charge, and Vitamin A Coupling. Gallic acid seems to have anti-fungal and anti-viral properties. In particular, gallic acid, an antioxidant present in foods like tea and wine and produced by the gut microbiota, can push potentially cancerous proteins to cause tumours in the colon. Gallic acid acts as a antioxidant and helps to protect our cells against oxidative damage. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 2.4. catechin and quercetin, also led to the synthesis of dextran molecules with antioxidant activity. It has a role as an astringent, a cyclooxygenase 2 inhibitor, a plant metabolite, an antioxidant, an antineoplastic agent, a human xenobiotic metabolite, an EC 1.13.11.33 ( arachidonate 15-lipoxygenase) inhibitor and an apoptosis inducer. Polyphenols form an important class of naturally occurring antioxidants, having innumerable biological activities such as anticancer, antifungal, antibacterial, antiviral, antiulcer and anticholesterol, to name a few. Our results are similar to those reported by Rice-Evans et al. In addition, numerous studies have reported that antioxidants possess antiviral activities. You do not have JavaScript enabled. Go to our  |  2.3. Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice. 200452(2), pp 255–260. Biochem Biophys Rep. 2020 Jun 9;23:100772. doi: 10.1016/j.bbrep.2020.100772. The differences in levels …  |  to access the full features of the site or access our, Computational Chemistry Laboratory, Department of Chemistry, University of Delhi, Delhi-110007, India, Chemistry for Medicine: Special Collection for RSC Advances, Instructions for using Copyright Clearance Center page. It is found in large quantities in green tea and is easily extracted Values in percentage ranged from 27.26 to 89.78%. Epub 2013 Jun 4. 2020 Dec;58(1):590-596. doi: 10.1080/13880209.2020.1777169. Grape seeds and skins are good sources of phytochemicals such as gallic acid, catechin, and epicatechin and are suitable raw materials for the production of antioxidative dietary supplements. Jiang R, Xu XH, Wang K, Yang XZ, Bi YF, Yan Y, Liu JZ, Chen XN, Wang ZZ, Guo XL, Zhao DQ, Sun LW. 2020 Jun 9;25(11):2683. doi: 10.3390/molecules25112683. Gallic acid (A), chlorogenic acid (B), protocatechuic acid (C) and vanillic acid (D). Computational Chemistry Laboratory, Department of Chemistry, University of Delhi, Delhi-110007, India Gallic acid … Certain animal studies, such as the one published in the May 2010 issue of the “Journal of Pharmacy and Pharmacology,” indicate that gallic acid possesses significant antioxidant activity and may protect the liver from the harmful effects of free radicals that are formed as a result of various metabolic processes in the body 1⭐⭐This is a verified and trusted source Goto Source . In this present work, I attempted to investigate the effect of Gallic acid derivatives have also been found in a number of phytomedicines with diverse biological and pharmacological activities, including radical scavenging, interfering with the cell signaling pathways and apoptosis of cancer cells. Biol Pharm Bull. Furthermore, data on murine tyrosinase activity and melanin biosynthesis revealed that GA effectively suppressed murine tyrosinase action and the amount of melanin. Gallic acid with the lowest hydrophobicity (log P=-0.28) was found to be the most active antiradical agent (IC50=29.5 μM), followed by methyl gallate (IC50=38.0 μM, log P=-0.23) and α-tocopherol (IC50=105.3 μM, log P=0.70). In this current study, the effects of GA on mushroom tyrosinase, tyrosinase inhibitory activity, and melanin content were assessed in B16 melanoma cells (B16 cells). 2017 Aug 17;208:149-156. doi: 10.1016/j.jep.2017.07.004. Mori T, Koyama N, Yokoo T, Segawa T, Maeda M, Sawmiller D, Tan J, Town T. J Biol Chem. lic acid (GA, 3,4,5-trihydroxybenzoic acid) is a naturally oc-curring polyphenol antioxidant that was recently shown to have potentially healthy effects16); however, the inhibitory action of GA on skin melanogenesis has not been fully explored. antioxidants Article Gallic Acid-Laminarin Conjugate Is a Better Antioxidant than Sulfated or Carboxylated Laminarin Marília Medeiros Fernandes-Negreiros 1, Lucas Alighieri Neves Costa Batista 1, Rony Lucas Silva Viana 1, Diego Araujo Sabry 1, Almino Afonso Oliveira Paiva 2, Weslley Souza Paiva 1, Raynara Iusk Araujo Machado 1, Francimar Lopes de Sousa Junior 3, Gallic acid (A) had the highest antioxidant capacity with 61% RSA, followed by protocatechuic acid (B), 35% RSA; chlorogenic acid (C), 28% RSA and vanillic acid had the lowest value of 11% RSA. If you are the author of this article you do not need to formally request permission Gallic acid is a water soluble phenolic acid present in grapes and in the leaves of many plants. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Gallic acid (3,4,5-trihydroxy benzoic acid; GA) is a natural phenolic compound with low toxicity and is produced by dierent plants. Journal of Agricultural and Food Chemistry 2013 , 61 (26) , 6533-6543. E-mail: "Reproduced from" can be substituted with "Adapted from". Abstract:Grape seeds and skins are good sources of phytochemicals such as gallic acid, catechin, and epicatechin and are suitable raw materials for the production of antioxidative dietary supplements. 2013;36(8):1341-7. doi: 10.1248/bpb.b13-00276. contained in this article in third party publications The Pseudophase Model Interpretation of the “Cutoff Effect”. If you are the author of this article you still need to obtain permission to reproduce eCollection 2020. Instructions for using Copyright Clearance Center page for details. Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressing. ORAC (Oxygen Radical Absorbance Capacity) ORAC (Oxygen Radical Absorbance Capacity) values are a measure of the antioxidant activity. Second, under the oxidation conditions applied, it was observed that the hydrophilic and/or lipophilic character affects drastically the antioxidant activity of gallic acid derivatives. Free radicals may be the result of stress, diet, alcohol, prescription medications, smoking, physical exercise, inflammation, or exposure to air pollutants and sunlight. with the reproduced material. Gallic acid is a very important common antioxidant tea formulation, known as an Ayurvedic herb. Antioxidant activity of extracts were expressed as percentage of DPPH radicals inhibition and IC50 values (µg/ml). This is followed by an account of their potential clinical and industrial applications. Biol Pharm Bull. This site needs JavaScript to work properly. However, gallic acid itself also appears to have antioxidant, anticarcinogenic and antiangiogenic activity in vitro. It is classified as a phenolic acid. In this current study, the effects of GA on mushroom tyrosinase, tyrosinase inhibitory activity, and melanin content were assessed in B16 melanoma cells (B16 cells). Gallic acid (GA) is a natural phenolic compound that possesses various biological effects, including antioxidant, anti‑inflammatory, antibiotic, anticancer, antiviral and cardiovascular protection activities. Oxidative stress, a result of an overproduction and accumulation of free radicals, is the leading cause of several degenerative diseases such as cancer, atherosclerosis, cardiovascular diseases, ageing and inflammatory diseases. Gallic acid h as been reported t o exert both pro-oxidant and antioxidant activities [13]. Gallic acid (GA) is a natural antioxidant that occurs mostly in black radish, certain red fruits, and red onions. formally request permission using Copyright Clearance Center. Deoxyribose assay. Reproduced material should be attributed as follows: If the material has been adapted instead of reproduced from the original RSC publication Gallic acid acts as an antioxidant and helps to protect human cells against oxidative damage. Int J Nanomedicine. This compound has antioxidant properties (an antioxidant is a substance that protects the body’s cells from the harmful free radicals) and helps to protect our cells against oxidative damage. Epub 2017 Jul 8. 2007 Nov;30(11):2007-11. doi: 10.1248/bpb.30.2007. Gallic acid was found to show cytotoxicity against cancer cells, without harming healthy cells. 2020 Oct 16;15:7995-8018. doi: 10.2147/IJN.S270242. NLM Neobavaisoflavone Inhibits Melanogenesis through the Regulation of Akt/GSK-3β and MEK/ERK Pathways in B16F10 Cells and a Reconstructed Human 3D Skin Model. To find novel skin-whitening agents, the melanogenesis inhibitory action of gallic acid (GA) was investigated. Clipboard, Search History, and several other advanced features are temporarily unavailable. Molecules. Determination of the reducing power. Please enable JavaScript Corresponding authors, a Panich U, Onkoksoong T, Limsaengurai S, Akarasereenont P, Wongkajornsilp A. J Photochem Photobiol B. Gallic acid is also used to … Rhamnetin attenuates melanogenesis by suppressing oxidative stress and pro-inflammatory mediators. UVA-induced melanogenesis and modulation of glutathione redox system in different melanoma cell lines: the protective effect of gallic acid. Gallic acid is a trihydroxybenzoic acid with the formula C6H2(OH)3CO2H. of the whole article in a thesis or dissertation. do not need to formally request permission to reproduce material contained in this In this current study, the effects of GA on mushroom tyrosinase, tyrosinase inhibitory activity, and melanin content were assessed in B16 melanoma cells (B16 cells). 2007 Jun;30(6):1135-9. doi: 10.1248/bpb.30.1135. eCollection 2020 Sep. Kim DE, Chang BY, Ham SO, Kim YC, Kim SY. COVID-19 is an emerging, rapidly evolving situation. J Ethnopharmacol. Piceatannol inhibits melanogenesis by its antioxidative actions. to reproduce figures, diagrams etc. The unstable free radicals may interact with DNA and proteins of the human cells and damage them. This article is part of the themed collection: For reproduction of material from all other RSC journals and books: For reproduction of material from all other RSC journals. Authors contributing to RSC publications (journal articles, books or book chapters) Epub 2011 Dec 28. the whole article in a third party publication with the exception of reproduction Among various polyphenols, gallic acid (3,4,5-trihydroxybenzoic acid), a naturally occurring low molecular weight triphenolic compound, has emerged as a strong antioxidant and an efficient apoptosis inducing agent. Gallic acid can also be used as a starting material in the synthesis of the psychedelic alkaloid mescaline. Gallic acid acts as a antioxidant and helps to protect our cells against oxidative damage. It is important to recognise that the observed association between protection by GA and protection of GSH cannot in itself establish that an increase in intracellular GSH is responsible for the protective effects of gallic acid—it could equally infer that gallic acid or delphinidin offers direct antioxidant protection resulting in protection of GSH. To find novel skin-whitening agents, the melanogenesis inhibitory action of gallic acid (GA) was investigated. Salts and esters of gallic acid are termed "gallates". The anti-peroxide activity in the bulk oil system decreased in the order of methyl gallate>gallic acid>α-tocopherol. Apart from its phytochemical role, gallic acid is also used in tanning, ink dyes, and the manufacture of paper. Radwan SAA, El-Maadawy WH, Yousry C, ElMeshad AN, Shoukri RA. Meyer and its main constituents inhibit α-melanocyte-stimulating hormone-induced melanogenesis by suppressing oxidative stress in B16 mouse melanoma cells. Among various polyphenols, gallic acid (3,4,5-trihydroxybenzoic acid), a naturally occurring low molecular weight triphenolic compound, has emerged as a … However, as with other cases, us… Results indicated that GA has a strong antityrosinase activity (IC50=3.59x10 (-6) M). It is a conjugate acid of a gallate. Biol Pharm Bull. P53 and cancer Every cell in our body has a gene called TP53 which produces a protein called p53. Results indicated that GA has a strong antityrosinase activity (IC50=3.59x10(-6) M). Gallic acid is used as a remote astringent in cases of internal haemorrhage. Gallic acid (GA), that is, 3,4,5-trihydroxybenzoic acid, is a naturally occurring polyphenol commonly found in a variety of fruits and vegetables such as grapes, green tea, tea leaves or tomatoes [  |  To investigate the relation between GA's inhibition of melanogenesis and antioxidant activity, the effect of GA on reactive species (RS) generation and the reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio in were determined in B16 cells. HHS Normal biochemical reactions, increased exposure to the environment, and higher levels of dietary xenobiotics result in the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS).2 ROS and RNS are responsible for the oxidative stress in different pathophysiological conditions.3 Cellular constituents of our body are altered in oxidative stress conditions, resulting in various disease states. * Esmaeilzadeh M, Heidarian E, Shaghaghi M, Roshanmehr H, Najafi M, Moradi A, Nouri A. Pharm Biol. Results indicated that GA effectively down-regulated the RS generation and enhanced the GSH/GSSG ratio. Gallic acid is an antioxidant which can inhibit both COX-2. Epub 2020 Sep 10. or in a thesis or dissertation provided that the correct acknowledgement is given Gallic Acid A potent antioxidant also found in black tea and red wine, shown in tests to inhibit cell proliferation and cell death in prostrate cancer cells. 2012 Mar 1;108:16-22. doi: 10.1016/j.jphotobiol.2011.12.004. The authors in this book discuss the natural occurrences, antioxidant properties and health implications of gallic acid. article provided that the correct acknowledgement is given with the reproduced material. To find novel skin-whitening agents, the melanogenesis inhibitory action of gallic acid (GA) was investigated. Gallic acid is a well-known natural antioxidant that is basically a secondary polyphenolic metabolite. NIH The total phenolic content ranged from 27.26 to 89.78 mg/g of dry weight of extract, expressed as gallic acid equivalents. gallic acid—it could equally infer that gallic acid or delphini-din offers direct antioxidant protection resulting in protec-tion of GSH. Specifically, the invention involves the use of gallic acid in the multiple roles of antioxidant, grain refiner, selective precipitant, and selective chelator in methanesulfonic acid based tin or … Based on these results, I propose that GA exerts antimelanogenic activity coupled with antioxidant properties by suppressing RS generation and maintaining a higher GSH/GSSG ratio. However, we consider the latter explanation to be unlikely on account of the lack of antioxidant activity of gallic acid at the relevant concentration (1 μM) in any of the antioxidant … Antioxidant and pro-oxidant properties of ascorbic acid and gallic acid. XX is the XXth reference in the list of references. The Gallic acid esters, such as tannins, catechin gallates and aliphatic gallates are potent antioxidants in vitro. 2020 Nov 27;295(48):16251-16266. doi: 10.1074/jbc.RA119.012330. Please enable it to take advantage of the complete set of features! it in a third party non-RSC publication you must They can cause significant damage to parts of cells such as DNA, proteins, an… It is found in gallnuts, sumac, witch hazel, tea leaves, oak bark, and other plants. The existing literature on this dual behavior of gallic acid and its derivatives is reviewed here. Maxima in Antioxidant Distributions and Efficiencies with Increasing Hydrophobicity of Gallic Acid and Its Alkyl Esters. If you are not the author of this article and you wish to reproduce material from Would you like email updates of new search results? In all cases the Ref. This may take some time to load. Gallic acid, ascorbic acid, ferrozine, ferric chloride hexahydrate, trypan blue, triton X-lOO, ethidium bromide (EtBr) and N-lauroyl ... 2.2. Barua N, Ibn Aziz MA, Tareq AM, Sayeed MA, Alam N, Alam NU, Uddin MA, Lyzu C, Emran TB. Ethyl acetate extract from Panax ginseng C.A. 2.1. Inhibitory effect of p-hydroxybenzyl alcohol on tyrosinase activity and melanogenesis. Recently, Curcumin showed higher antioxidant activity than ascorbic acid and xanthone but less than Gallic acid on the free radical scavenging action . Materials. Information about reproducing material from RSC articles with different licences Tel: +91-1127666313. In B16F10 cells and a Reconstructed human 3D Skin Model anti-fungal and anti-viral properties effect always... Solid, although samples are typically brown owing to partial oxidation 13 ] their. Antioxidants possess antiviral activities modulator that reverses cognitive impairment and remediates pathology in mice... 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